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KMID : 1040020110020010018
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International Journal of Pain
2011 Volume.2 No. 1 p.18 ~ p.25
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The Effect of Pregabalin on Pain Control after Tonsillectomy in Adults
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Kim Tae-Sung
Kang Sin-Kyu
Park Jung-Man
Bae Jun-Seok
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Abstract
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Background: Pregabalin is a novel antiepileptic agent and has demonstrated analgesic effects in acute postoperative pain management. In this study, we studied the effectiveness of preemptive analgesia using pregabalin on pain control after tonsillectomy.
Methods: Forty-four adults were randomly received either placebo or pregabalin, respectively, as premedication one hour before surgery. We evaluated the number of diclofenac sodium injections, the total amount of remifentanil consumption and adverse effects during 48 hours after tonsillectomy. In addition, pain assessment was performed using a visual analog scale during resting (rVAS) and swallowing periods (sVAS) during 48 hours after the operation. Furthermore, incidences of side-effects were evaluated.
Results: The cumulative remifentanil consumption and dicolfenac sodium requirements were significantly decreased in pregabalin group during 24 and 48 hours after tonsillectomy, respectively (P < 0.05). The rVAS and sVAS of the pregabalin group were also significantly lower than that of the control group at 2 and 4 hours after tonsillectomy (P < 0.05). However, we did not observe a significant difference in the incidence of adverse effects between the two groups.
Conclusions: Although pregabalin do not reduce the incidence of side-effects, pregabalin effectively reduced remifentanil requirements and postoperative pain after tonsillectomy. Pregabalin has preemptive analgesic effect on tonsillectomy and may be useful in the management of acute pain control after tonsillectomy.
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KEYWORD
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pregabalin, remifentanil, tonsillectomy, visual analog scale
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